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BPC194
General Information
DCTPep ID DCTPep02168
Peptide Name BPC194
Sequence KKLKKFKKLQ
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | 70 ± 0.01% Growth inhibition=40 μM; IC50=32.5 ± 0.5 μM | MTT assay | 48 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=29.5 ± 2 μM | MTT assay | 48 h | 1 |
| PANC-1 | Pancreatic ductal adenocarcinoma | IC50=40.0 ± 3 μM | MTT assay | 48 h | 1 |
| HepG2 | Hepatoblastoma | IC50=46.0 ± 3 μM | MTT assay | 48 h | 1 |
| A431 | Skin squamous cell carcinoma | IC50=50.0 ± 10 μM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 17 ± 1.7% Hemolysis=375 µM; IC50=17 ± 1.7 µM
Normal (non-cancerous) Cytotoxicity Human non-malignant fibroblasts: IC50=56.5 ± 0.7 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Lys1<--->Gln10
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C62H113N17O12
Absent amino acids ACDEGHIMNPRSTVWY
Theoretical pI 10.70
Acidic residues 0
Basic residues 6
Polar residues 0
Molecular weight (Average) 1288.69
Molecular weight (Monoisotopic) 1287.88
Common amino acids K
Net charge 6
Instability index (II) 1.1
Aliphatic index 78.00
Grand average of hydropathicity (GRAVY) -1.650
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20708052
Title Antimicrobial cyclic decapeptides with anticancer activity
Doi 10.1016/j.peptides.2010.07.027
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3062
This work is licensed under a Creative Commons Attribution 4.0 International License.