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PMAP-23, Myeloid antibacterial peptide 23
General Information
DCTPep ID DCTPep02174
Peptide Name PMAP-23, Myeloid antibacterial peptide 23
Sequence RIIDLLWRVRRPQKPKFVTVWVR
Sequence Length 23
UniProt ID P49930
PubChem CID 16130705
Origin Sus scrofa
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | IC50=35 µM | MTT assay | 3 days | 1 |
| SNU-601 | Gastric signet ring cell adenocarcinoma | IC50=47 µM | MTT assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: 4.8% Hemolysis=100 µM
Normal (non-cancerous) Cytotoxicity Human keratinocytes HaCat: 25% Killing=100 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02174
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C140H229N43O28
Absent amino acids ACEGHMNSY
Theoretical pI 12.18
Acidic residues 1
Basic residues 7
Polar residues 1
Molecular weight (Average) 2962.63
Molecular weight (Monoisotopic) 2960.78
Common amino acids R
Net charge 6
Instability index (II) 50.85
Aliphatic index 118.26
Grand average of hydropathicity (GRAVY) -0.296
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 3.713
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12054589
Title Design of novel peptide analogs with potent fungicidal activity, based on PMAP-23 antimicrobial peptide isolated from porcine myeloid
Doi 10.1016/S0006-291X(02)00222-X
Year 2002
Literature 2
Pubmed ID 20512598
Title C-terminal amidation of PMAP-23: translocation to the inner membrane of Gram-negative bacteria
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3050
This work is licensed under a Creative Commons Attribution 4.0 International License.