This work is licensed under a Creative Commons Attribution 4.0 International License.
PMAP-23 [K14W]
General Information
DCTPep ID DCTPep02177
Peptide Name PMAP-23 [K14W]
Sequence RIIDLLWRVRRPQWPKFVTVWVR
Sequence Length 23
UniProt ID P49930
PubChem CID 16129744
Origin Synthetic (Derived from PMAP-23)
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | IC50=29 µM | MTT assay | 3 days | 1 |
| SNU-601 | Gastric signet ring cell adenocarcinoma | IC50=39 µM | MTT assay | 3 days | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02177
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C145H227N43O28
Absent amino acids ACEGHMNSY
Theoretical pI 12.18
Acidic residues 1
Basic residues 6
Polar residues 1
Molecular weight (Average) 3020.67
Molecular weight (Monoisotopic) 3018.77
Common amino acids R
Net charge 5
Instability index (II) 54.13
Aliphatic index 118.26
Grand average of hydropathicity (GRAVY) -0.165
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 5.462
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12054589
Title Design of novel peptide analogs with potent fungicidal activity, based on PMAP-23 antimicrobial peptide isolated from porcine myeloid
Doi 10.1016/S0006-291X(02)00222-X
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3053
This work is licensed under a Creative Commons Attribution 4.0 International License.