PMAP-23 [R10W][Q13W]

General Information


DCTPep ID  DCTPep02179

Peptide Name   PMAP-23 [R10W][Q13W]

Sequence  RIIDLLWRVWRPWKPKFVTVWVR

Sequence Length  23

UniProt ID  P49930 

PubChem CID  16129746 

Origin  Synthetic (Derived from PMAP-23)

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia IC50=16 µM MTT assay 3 days 1
SNU-601 Gastric signet ring cell adenocarcinoma IC50=21 µM MTT assay 3 days 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02179

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C151H229N41O27

Absent amino acids  ACEGHMNQSY

Theoretical pI  12.01

Acidic residues  1

Basic residues  6

Polar residues  1

Molecular weight (Average)  3050.74

Molecular weight (Monoisotopic)  3048.78

Common amino acids  RVW

Net charge  5

Instability index (II)  16.32

Aliphatic index  118.26

Grand average of hydropathicity (GRAVY)  -0.026

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  2 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 22000
  Abs 0.1% (=1 g/l) 7.211

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 12054589

Title  Design of novel peptide analogs with potent fungicidal activity, based on PMAP-23 antimicrobial peptide isolated from porcine myeloid

Doi 10.1016/S0006-291X(02)00222-X

Year  2002

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_3055

DCTPep is developed by Dr.Zheng's team.