Peptide Libraray

Ano-D4,7–4C8

General Information

DCTPep ID DCTPep02189

Peptide Name Ano-D4,7–4C8

Sequence GLLxRIkTLL

Sequence Length 10

UniProt ID Not available

PubChem CID Not available

Origin Synthetic (Derived from Anoplin)

Type Synthetic peptide

Classification

Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	IC50>256 µM	MTT assay	1 h	1

Hemolytic Activity Mouse erythrocytes: 10% Hemolysis>256 µM

Normal (non-cancerous) Cytotoxicity HEK293T: IC50>256 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification x=D-Lys-C8 (D-Lysine with octanoylated side group); k=D-Lys

Chiral Mix

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 31676352

Title Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria

Doi 10.1016/j.ejps.2019.105123

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available