This work is licensed under a Creative Commons Attribution 4.0 International License.
Ano-D4,7–4C12
General Information
DCTPep ID DCTPep02191
Peptide Name Ano-D4,7–4C12
Sequence GLLxRIkTLL
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from Anoplin)
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=16 µM | MTT assay | 1 h | 1 |
Hemolytic Activity Mouse erythrocytes: 10% Hemolysis=32 µM
Normal (non-cancerous) Cytotoxicity HEK293T: IC50=32 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification x=D-Lys-C12 (D-Lysine with laurylated side group); k=D-Lys
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31676352
Title Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria
Doi 10.1016/j.ejps.2019.105123
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 14369
This work is licensed under a Creative Commons Attribution 4.0 International License.