Decoralin [AC2]

General Information


DCTPep ID  DCTPep02202

Peptide Name   Decoralin [AC2]

Sequence  RLLRLIRKLIL

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic (Derived from Decoralin)

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane lysis Cell-penetrating peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma EC50=14±1 μM MTT assay 24/72 h 1
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia EC50=25±1 μM MTT assay 24/72 h 1
1205Lu Melanoma EC50=7±1 μM MTT assay 24/72 h 1
MCF-7 Invasive breast carcinoma of no special type EC50=9±1 μM MTT assay 24/72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HDMEC: EC50=125–250 μM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C66H127N21O12

Absent amino acids  ACDEFGHMNPQSTVWY

Theoretical pI  12.30

Acidic residues  0

Basic residues  4

Polar residues  0

Molecular weight (Average)  1406.87

Molecular weight (Monoisotopic)  1406

Common amino acids  L

Net charge  4

Instability index (II)  36.39

Aliphatic index  248.18

Grand average of hydropathicity (GRAVY)  0.964

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  2 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 26119906

Title  Multidimensional Design of Anticancer Peptides

Doi 10.1002/anie.201504018

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.