This work is licensed under a Creative Commons Attribution 4.0 International License.
Decoralin [AT7]
General Information
DCTPep ID DCTPep02218
Peptide Name Decoralin [AT7]
Sequence CLLLLIRKLIL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from Decoralin)
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane lysis Tumor-homing peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| 1205Lu | Melanoma | EC50=76±1 μM | MTT assay | 24/72 h | 1 |
| A549 | Lung adenocarcinoma | EC50>100 μM | MTT assay | 24/72 h | 1 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | EC50>100 μM | MTT assay | 24/72 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | EC50>100 μM | MTT assay | 24/72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HDMEC: EC50~=500 μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C63H119N15O12S1
Absent amino acids ADEFGHMNPQSTVWY
Theoretical pI 9.51
Acidic residues 0
Basic residues 2
Polar residues 1
Molecular weight (Average) 1310.79
Molecular weight (Monoisotopic) 1309.89
Common amino acids L
Net charge 2
Instability index (II) 36.39
Aliphatic index 283.64
Grand average of hydropathicity (GRAVY) 2.355
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26119906
Title Multidimensional Design of Anticancer Peptides
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.