Tyrocidine C1, TrcC1

General Information


DCTPep ID  DCTPep02273

Peptide Name   Tyrocidine C1, TrcC1

Sequence  VKLfPWwNQY

Sequence Length  10

UniProt ID  Not available

PubChem CID  45485350 

Origin  Bacillus aneurinolyticus; Bacillus brevis

Type  Native peptide

Classification

  

ACP Tumor active peptide Membrane lysis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma LC50=12 µM Resazurin assay 24 h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma LC50=16 µM Resazurin assay 24 h 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis=5.4 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Val1<--->Tyr10

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  f=D-Phe

Chiral  Mix



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 17462586

Title  Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis

Doi 10.1016/j.bbamem.2007.01.015

Year  2007

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPN_6094

DCTPep is developed by Dr.Zheng's team.