Peptide Libraray

VmCT1-NH2

General Information

DCTPep ID DCTPep02277

Peptide Name VmCT1-NH2

Sequence FLGALWNVAKSVF

Sequence Length 13

UniProt ID I0DEB3

PubChem CID Not available

Origin Vaejovis mexicanus smithi

Type Native peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	12.5 µM	MTT assay	24 h	1

Hemolytic Activity Human erythrocytes: ~0% Hemolytic=6.3 µM

Normal (non-cancerous) Cytotoxicity MCF-10A: Not active up to 25 μM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02277

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C72H106N16O16

Absent amino acids CDEHIMPQRTY

Theoretical pI 8.75

Acidic residues 0

Basic residues 1

Polar residues 3

Molecular weight (Average) 1451.73

Molecular weight (Monoisotopic) 1450.8

Common amino acids AFLV

Net charge 1

Instability index (II) 30.41

Aliphatic index 120.00

Grand average of hydropathicity (GRAVY) 1.208

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.789

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 31181304

Title The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1

Doi 10.1016/j.ejps.2019.06.006

Year 2019

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_3475