Peptide Libraray

[Lys]1[Lys]12-VmCT1-NH2

General Information

DCTPep ID DCTPep02280

Peptide Name [Lys]1[Lys]12-VmCT1-NH2

Sequence KLGALWNVAKSKF

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	>100 µM	MTT assay	24 h	1

Hemolytic Activity Human erythrocytes: ~0% Hemolytic>100 µM

Normal (non-cancerous) Cytotoxicity MCF-10A: Not active up to 25 μM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02280

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C70H112N18O16

Absent amino acids CDEHIMPQRTY

Theoretical pI 10.30

Acidic residues 0

Basic residues 3

Polar residues 3

Molecular weight (Average) 1461.77

Molecular weight (Monoisotopic) 1460.85

Common amino acids K

Net charge 3

Instability index (II) 23.88

Aliphatic index 97.69

Grand average of hydropathicity (GRAVY) 0.069

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.763

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 31181304

Title The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1

Doi 10.1016/j.ejps.2019.06.006

Year 2019

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_16790