[Lys]3[Lys]7-VmCT1-NH2

General Information


DCTPep ID  DCTPep02281

Peptide Name   [Lys]3[Lys]7-VmCT1-NH2

Sequence  FLKALWKVAKSVF

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane lysis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type 12.5 µM MTT assay 24 h 1

Hemolytic Activity  Human erythrocytes: ~0% Hemolytic=1.6 µM

Normal (non-cancerous) Cytotoxicity  MCF-10A: Not active up to 25 μM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02281

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C78H121N17O15

Absent amino acids  CDEGHIMNPQRTY

Theoretical pI  10.30

Acidic residues  0

Basic residues  3

Polar residues  1

Molecular weight (Average)  1536.92

Molecular weight (Monoisotopic)  1535.92

Common amino acids  K

Net charge  3

Instability index (II)  14.38

Aliphatic index  120.00

Grand average of hydropathicity (GRAVY)  0.908

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 3.579

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31181304

Title  The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1

Doi 10.1016/j.ejps.2019.06.006

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_16791

DCTPep is developed by Dr.Zheng's team.