Peptide Libraray

Temporin-1Oc

General Information

DCTPep ID DCTPep02285

Peptide Name Temporin-1Oc

Sequence FLPLLASLFSRLF

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Rana ornativentris

Type Native peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	LC50=50 μM	MTS assay	Not available	1
4T1	Malignant neoplasms of the mouse mammary gland	LC50=65 μM	MTS assay	Not available	1

Hemolytic Activity Human erythrocytes: 50% Hemolysis<12.5 µM

Normal (non-cancerous) Cytotoxicity HaCat: LC50=50 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02285

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C77H118N16O16

Absent amino acids CDEGHIKMNQTVWY

Theoretical pI 9.75

Acidic residues 0

Basic residues 1

Polar residues 2

Molecular weight (Average) 1523.88

Molecular weight (Monoisotopic) 1522.89

Common amino acids L

Net charge 1

Instability index (II) 38.86

Aliphatic index 157.69

Grand average of hydropathicity (GRAVY) 1.654

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 29842923

Title Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins

Doi 10.1016/j.peptides.2018.05.011

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_4935