Temporin-1Oc

General Information


DCTPep ID  DCTPep02285

Peptide Name   Temporin-1Oc

Sequence  FLPLLASLFSRLF

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Rana ornativentris

Type  Native peptide

Classification

  

ACP Tumor active peptide Membrane lysis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma LC50=50 μM MTS assay Not available 1
4T1 Malignant neoplasms of the mouse mammary gland LC50=65 μM MTS assay Not available 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis<12.5 µM

Normal (non-cancerous) Cytotoxicity  HaCat: LC50=50 µM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02285

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C77H118N16O16

Absent amino acids  CDEGHIKMNQTVWY

Theoretical pI  9.75

Acidic residues  0

Basic residues  1

Polar residues  2

Molecular weight (Average)  1523.88

Molecular weight (Monoisotopic)  1522.89

Common amino acids  L

Net charge  1

Instability index (II)  38.86

Aliphatic index  157.69

Grand average of hydropathicity (GRAVY)  1.654

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29842923

Title  Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins

Doi 10.1016/j.peptides.2018.05.011

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPR_4935

DCTPep is developed by Dr.Zheng's team.