This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-CPa
General Information
DCTPep ID DCTPep02286
Peptide Name Temporin-CPa
Sequence IPPFIKKVLTTVF
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Rana capito
Type Native peptide
Classification
ACP Tumor active peptide Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| 4T1 | Malignant neoplasms of the mouse mammary gland | LC50=80 μM | MTS assay | Not available | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | LC50>80 μM | MTS assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>100 µM
Normal (non-cancerous) Cytotoxicity HaCat: LC50=100 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02286
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C76H123N15O16
Absent amino acids ACDEGHMNQRSWY
Theoretical pI 10.00
Acidic residues 0
Basic residues 2
Polar residues 2
Molecular weight (Average) 1502.9
Molecular weight (Monoisotopic) 1501.93
Common amino acids FIKPTV
Net charge 2
Instability index (II) 23.58
Aliphatic index 134.62
Grand average of hydropathicity (GRAVY) 1.108
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29842923
Title Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins
Doi 10.1016/j.peptides.2018.05.011
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3483
This work is licensed under a Creative Commons Attribution 4.0 International License.