Peptide Libraray

Pantinin-1

General Information

DCTPep ID DCTPep02287

Peptide Name Pantinin-1

Sequence GILGKLWEGFKSIV

Sequence Length 14

UniProt ID R4JNJ5

PubChem CID 102602714

Origin Pandinus imperator

Type Native peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MDA-MB-231	Breast adenocarcinoma	IC50=28.5 ± 1.0 μM	MTS assay	24 h	1
DU145	Prostate carcinoma	IC50=47.5 ± 2.0 μM	MTS assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HGF-1: IC50=97.5 ± 1.0 μM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02287

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C75H119N17O18

Absent amino acids ACDHMNPQRTY

Theoretical pI 8.59

Acidic residues 1

Basic residues 2

Polar residues 4

Molecular weight (Average) 1546.87

Molecular weight (Monoisotopic) 1545.89

Common amino acids G

Net charge 1

Instability index (II) 4.96

Aliphatic index 132.14

Grand average of hydropathicity (GRAVY) 0.671

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.556

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30409511

Title Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom

Doi 10.1016/j.bbamem.2018.08.012

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_3490