This work is licensed under a Creative Commons Attribution 4.0 International License.
[Ser18,Ser24]-brevinin-1BYa
General Information
DCTPep ID DCTPep02293
Peptide Name [Ser18,Ser24]-brevinin-1BYa
Sequence FLPILASLAAKFGPKLFSLVTKKS
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | LC50=10 μM | CytoTox 96 non-radiactive cytotoxicity assay | 1 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | LC50=13 μM | CellTiter-Glo Luminescent Cell Viability assay | 24, 48 h | 1 |
Hemolytic Activity Human erythrocytes: LC50=75 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02293
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Ser18<--->Ser24
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C126H206N28O29
Absent amino acids CDEHMNQRWY
Theoretical pI 10.48
Acidic residues 0
Basic residues 4
Polar residues 5
Molecular weight (Average) 2577.19
Molecular weight (Monoisotopic) 2575.55
Common amino acids L
Net charge 4
Instability index (II) 18.56
Aliphatic index 122.08
Grand average of hydropathicity (GRAVY) 0.800
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21312033
Title Synthesis, conformational analysis and biological properties of a dicarba derivative of the antimicrobial peptide, brevinin-1BYa
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4418
This work is licensed under a Creative Commons Attribution 4.0 International License.