Peptide Libraray

Granulysin (23-51)

General Information

DCTPep ID DCTPep02308

Peptide Name Granulysin (23-51)

Sequence QRSVSNAATRVCRTGRSRWRDVCRNFMRR

Sequence Length 29

UniProt ID P22749

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Induce apoptosis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Jurkat	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	90% Cell death=20 µM	PI assay	4 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02308

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys12<--->Cys23

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C142H242N60O40S3

Absent amino acids EHIKLPY

Theoretical pI 12.10

Acidic residues 1

Basic residues 9

Polar residues 10

Molecular weight (Average) 3526.04

Molecular weight (Monoisotopic) 3523.79

Common amino acids R

Net charge 8

Instability index (II) 79.65

Aliphatic index 36.90

Grand average of hydropathicity (GRAVY) -1.162

Half Life
0.8 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5625
Abs 0.1% (=1 g/l) 1.595, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.560, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 10903754

Title Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin

Doi 10.4049/jimmunol.165.3.1486

Year 2000

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_3867