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Granulysin (42-51)
General Information
DCTPep ID DCTPep02311
Peptide Name Granulysin (42-51)
Sequence RDVCRNFMRR
Sequence Length 10
UniProt ID P22749
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Not active at 20 µM | PI assay | 4 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C54H93N23O14S2
Absent amino acids AEGHIKLPQSTWY
Theoretical pI 11.52
Acidic residues 1
Basic residues 4
Polar residues 2
Molecular weight (Average) 1352.6
Molecular weight (Monoisotopic) 1351.67
Common amino acids R
Net charge 3
Instability index (II) 56.05
Aliphatic index 29.00
Grand average of hydropathicity (GRAVY) -1.360
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10903754
Title Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin
Doi 10.4049/jimmunol.165.3.1486
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3870
This work is licensed under a Creative Commons Attribution 4.0 International License.