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Granulysin (23-41)
General Information
DCTPep ID DCTPep02313
Peptide Name Granulysin (23-41)
Sequence QRSVSNAATRVCRTGRSRW
Sequence Length 19
UniProt ID P22749
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Not active at 20 µM | PI assay | 4 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02313
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C88H151N37O27S1
Absent amino acids DEFHIKLMPY
Theoretical pI 12.18
Acidic residues 0
Basic residues 5
Polar residues 8
Molecular weight (Average) 2191.46
Molecular weight (Monoisotopic) 2190.13
Common amino acids R
Net charge 5
Instability index (II) 91.54
Aliphatic index 41.05
Grand average of hydropathicity (GRAVY) -1.058
Half Life
0.8 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.510, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.510, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10903754
Title Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin
Doi 10.4049/jimmunol.165.3.1486
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_3872
This work is licensed under a Creative Commons Attribution 4.0 International License.