Peptide Libraray

Granulysin (37-51) [R38Q][R40Q]

General Information

DCTPep ID DCTPep02315

Peptide Name Granulysin (37-51) [R38Q][R40Q]

Sequence GQSQWRDVCRNFMRR

Sequence Length 15

UniProt ID P22749

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Induce apoptosis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Jurkat	Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia	Not active at 20 µM	PI assay	4 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02315

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C80H127N31O22S2

Absent amino acids AEHIKLPTY

Theoretical pI 11.52

Acidic residues 1

Basic residues 4

Polar residues 4

Molecular weight (Average) 1939.2

Molecular weight (Monoisotopic) 1937.92

Common amino acids R

Net charge 3

Instability index (II) 82.83

Aliphatic index 19.33

Grand average of hydropathicity (GRAVY) -1.513

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.836, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.836, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 10903754

Title Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin

Doi 10.4049/jimmunol.165.3.1486

Year 2000

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_3874