This work is licensed under a Creative Commons Attribution 4.0 International License.
AamAP-S1, AamAP1 [H8K]
General Information
DCTPep ID DCTPep02318
Peptide Name AamAP-S1, AamAP1 [H8K]
Sequence FLFSLIPKAIGGLISAFK
Sequence Length 18
UniProt ID G8YYA5
PubChem CID 71596347
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| LNCaP | Prostate carcinoma | IC50=25.58 µM | MTT assay | 24 h | 1 |
| PC-3 | Prostate carcinoma | IC50=28 µM | MTT assay | 24 h | 1 |
| U251 | Astrocytoma | IC50=29.23 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Horse erythrocytes: 53% Hemolysis=100 µM; 52% Hemolysis=80 µM
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=40.35 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02318
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C96H152N20O21
Absent amino acids CDEHMNQRTVWY
Theoretical pI 10.00
Acidic residues 0
Basic residues 2
Polar residues 4
Molecular weight (Average) 1922.38
Molecular weight (Monoisotopic) 1921.14
Common amino acids FIL
Net charge 2
Instability index (II) 6.35
Aliphatic index 141.11
Grand average of hydropathicity (GRAVY) 1.394
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22484288
Title Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog
Doi 10.1016/j.peptides.2012.03.016
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_3886
This work is licensed under a Creative Commons Attribution 4.0 International License.