DCTPep ID  DCTPep02322

Peptide Name   Maximin-H5, MH5N

Sequence  ILGPVLGLVSDTLDDVLGIL

Sequence Length  20

UniProt ID  Q8JHE1  B5L100  B5L135  C3RSW1  C3RSW6  C3RSX2  C3RSY2 

PubChem CID  49777310 

Origin  Bombina maxima

Type  Native peptide

Hemolytic Activity  Human erythrocytes: 20% Hemolysis=90 µM

Normal (non-cancerous) Cytotoxicity  SVGp12: ~10% Cell death=125 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

PDB ID  Not available

Predicted Structure  DCTPep02322

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  1.480

Half Life 
  20 hours (mammalian reticulocytes, in vitro).
  30 min (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature 1

Pubmed ID 28249727

Title  Investigations into the potential anticancer activity of Maximin H5

Doi 10.1016/j.biochi.2017.02.013

Year  2017

Literature 2

Pubmed ID 25640709

Title  The role of C-terminal amidation in the membrane interactions of the anionic antimicrobial peptide, maximin H5

Doi 10.1016/j.bbamem.2015.01.014

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available

DBAASP ID  DBAASPR_3942