This work is licensed under a Creative Commons Attribution 4.0 International License.
Warnericin RK
General Information
DCTPep ID DCTPep02327
Peptide Name Warnericin RK
Sequence MQFITDLIKKAVDFFKGLFGNK
Sequence Length 22
UniProt ID F4ZBW5
PubChem CID Not available
Origin Staphylococcus warneri RK; Staphylococcus epidermidis
Type Native peptide
Classification
ACP Tumor active peptide Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | LD50=2.11 µM | PI staining assay | Not available | 1 |
| LNCaP | Prostate carcinoma | LD50=3.98 µM | PI staining assay | Not available | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | LD50=4.22 µM | PI staining assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: 10% Hemolysis=2.78 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02327
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C122H190N28O30S1
Absent amino acids CEHPRSWY
Theoretical pI 9.52
Acidic residues 2
Basic residues 4
Polar residues 4
Molecular weight (Average) 2561.08
Molecular weight (Monoisotopic) 2559.39
Common amino acids FK
Net charge 2
Instability index (II) -15.21
Aliphatic index 88.64
Grand average of hydropathicity (GRAVY) 0.209
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27598770
Title Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging
Doi 10.1371/journal.pone.0162007
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4146
This work is licensed under a Creative Commons Attribution 4.0 International License.