This work is licensed under a Creative Commons Attribution 4.0 International License.
Jindongenin-1a
General Information
DCTPep ID DCTPep02329
Peptide Name Jindongenin-1a
Sequence DSMGAVKLAKLLIDKMKCEVTKAC
Sequence Length 24
PubChem CID Not available
Origin Amolops jingdongensis
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HT-29 | Colon adenocarcinoma | IC50=40 µM | MTT assay | 48 h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | IC50=46 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=150 µM; Rabbit erythrocytes: 50% Hemolysis=150 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02329
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys18<--->Cys24
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C111H199N29O33S4
Absent amino acids FHNPQRWY
Theoretical pI 8.79
Acidic residues 3
Basic residues 5
Polar residues 5
Molecular weight (Average) 2596.22
Molecular weight (Monoisotopic) 2594.37
Common amino acids K
Net charge 2
Instability index (II) 30.61
Aliphatic index 101.67
Grand average of hydropathicity (GRAVY) 0.275
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.048, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21816202
Title Two novel families of antimicrobial peptides from skin secretions of the Chinese torrent frog, Amolops jingdongensis
Doi 10.1016/j.biochi.2011.07.021
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4194
This work is licensed under a Creative Commons Attribution 4.0 International License.