Peptide Libraray

Esculentin-2CHa [C31S, C37S]

General Information

DCTPep ID DCTPep02338

Peptide Name Esculentin-2CHa [C31S, C37S]

Sequence GFSSIFRGVAKFASKGLGKDLAKLGVDLVASKISKQS

Sequence Length 37

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	LC50=26 μM	CellTiter-Glo Luminescent Cell Viability assay	24 h	1

Hemolytic Activity Human erythrocytes: 50% Hemolysis>200 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02338

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C173H289N47O49

Absent amino acids CEHMNPTWY

Theoretical pI 10.30

Acidic residues 2

Basic residues 7

Polar residues 11

Molecular weight (Average) 3811.48

Molecular weight (Monoisotopic) 3809.16

Common amino acids KS

Net charge 5

Instability index (II) 17.68

Aliphatic index 97.57

Grand average of hydropathicity (GRAVY) 0.195

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23159562

Title Esculentin-2CHa: a host-defense peptide with differential cytotoxicity against bacteria, erythrocytes and tumor cells

Doi 10.1016/j.peptides.2012.11.004

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_4387