Peptide Libraray

PsT-1

General Information

DCTPep ID DCTPep02340

Peptide Name PsT-1

Sequence KPPPWVPV

Sequence Length 8

UniProt ID C0HJF6

PubChem CID Not available

Origin Phyllomedusa sauvagii

Type Native peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
DU145	Prostate carcinoma	~25% Cell death=10 µM	MTT assay	72 h	1
PC-3	Prostate carcinoma	~25% Cell death=10 µM	MTT assay	72 h	1
LNCaP	Prostate carcinoma	~50% Cell death=10 µM	MTT assay	72 h	1

Hemolytic Activity Horse erythrocytes: Not active up to 160 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C47H70N10O9

Absent amino acids ACDEFGHILMNQRSTY

Theoretical pI 8.75

Acidic residues 0

Basic residues 1

Polar residues 0

Molecular weight (Average) 919.13

Molecular weight (Monoisotopic) 918.53

Common amino acids P

Net charge 1

Instability index (II) 81.41

Aliphatic index 72.50

Grand average of hydropathicity (GRAVY) -0.350

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 5.984

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23518460

Title PsT-1: a new tryptophyllin peptide from the skin secretion of Waxy Monkey Leaf Frog, Phyllomedusa sauvagei

Doi 10.1016/j.regpep.2013.03.017

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_4274