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Cliotides T20, CT20
General Information
DCTPep ID DCTPep02345
Peptide Name Cliotides T20, CT20
Sequence GSAIRCGESCLLGKCYTPGCTCDRPICKKN
Sequence Length 30
UniProt ID Not available
PubChem CID Not available
Origin Clitoria ternatea
Type Native peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | IC50>10 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02345
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys6<--->Cys20; Cys10<--->Cys22; Cys15<--->Cys27; NCB: Gly1<--->Asn30
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C129H218N40O41S6
Absent amino acids FHMQVW
Theoretical pI 8.66
Acidic residues 2
Basic residues 5
Polar residues 16
Molecular weight (Average) 3177.75
Molecular weight (Monoisotopic) 3175.45
Common amino acids C
Net charge 3
Instability index (II) 46.39
Aliphatic index 55.33
Grand average of hydropathicity (GRAVY) -0.230
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1865
Abs 0.1% (=1 g/l) 0.587, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.469, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23419988
Title Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.