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DP1
General Information
DCTPep ID DCTPep02348
Peptide Name DP1
Sequence RRQRRTSKLMKRGGKLAKLAKKLAKLAKLAK
Sequence Length 31
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Coupling peptide Pro-apoptotic peptide Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Clinical isolate 22B | Human head tumor | LC50<50 μM | MTT assay | 3 h | 1 |
| Clinical isolate 4129 | Human neck tumor | LC50<50 μM | MTT assay | 3 h | 1 |
| MCA 205 | Mouse fibrosarcoma | LC50<50 μM | MTT assay | 3 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism It is possible that the DP1 fusion peptide can be used to facilitate an immune response against tumor antigens by triggering massive apoptosis within tumors
Structure Information
PDB ID Not available
Predicted Structure DCTPep02348
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C156H296N56O35S1
Absent amino acids CDEFHINPVWY
Theoretical pI 12.61
Acidic residues 0
Basic residues 14
Polar residues 4
Molecular weight (Average) 3548.48
Molecular weight (Monoisotopic) 3546.28
Common amino acids K
Net charge 14
Instability index (II) 45.43
Aliphatic index 91.61
Grand average of hydropathicity (GRAVY) -0.958
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11691780
Title A proapoptotic peptide for the treatment of solid tumors
Doi Not available
Year 2001
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4305
This work is licensed under a Creative Commons Attribution 4.0 International License.