This work is licensed under a Creative Commons Attribution 4.0 International License.
Pro-apoptotic peptide, PAP
General Information
DCTPep ID DCTPep02355
Peptide Name Pro-apoptotic peptide, PAP
Sequence KLAKLAKKLAKLAK
Sequence Length 14
UniProt ID Not available
PubChem CID 101725251
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | 82% Killing=10 µM ; 100% Killing=50 µM | CellTox cytotoxicity assay | 30 min | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02355
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C72H138N20O15
Absent amino acids CDEFGHIMNPQRSTVWY
Theoretical pI 10.70
Acidic residues 0
Basic residues 6
Polar residues 0
Molecular weight (Average) 1524.01
Molecular weight (Monoisotopic) 1523.06
Common amino acids K
Net charge 6
Instability index (II) -14.97
Aliphatic index 140.00
Grand average of hydropathicity (GRAVY) -0.071
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26734838
Title Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.