Peptide Libraray

Alyteserin-2b

General Information

DCTPep ID DCTPep02363

Peptide Name Alyteserin-2b

Sequence ILGAILPLVSGLLSNKL

Sequence Length 17

UniProt ID Not available

PubChem CID Not available

Origin Alytes obstetricans

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	LC50>100 µM	CellTiter-Glo Luminescent Cell Viability assay	24 h	1

Hemolytic Activity Human erythrocytes: 50% Hemolysis=115 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02363

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C81H145N19O21

Absent amino acids CDEFHMQRTWY

Theoretical pI 8.75

Acidic residues 0

Basic residues 1

Polar residues 5

Molecular weight (Average) 1721.16

Molecular weight (Monoisotopic) 1720.09

Common amino acids L

Net charge 1

Instability index (II) 47.34

Aliphatic index 206.47

Grand average of hydropathicity (GRAVY) 1.553

Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22392897

Title Analogues of the frog skin peptide alyteserin-2a with enhanced antimicrobial activities against Gram-negative bacteria

Doi 10.1002/psc.2397

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPR_4393