Peptide Libraray

PTP-7c

General Information

DCTPep ID DCTPep02377

Peptide Name PTP-7c

Sequence FLGALFHALSHLL

Sequence Length 13

UniProt ID P80399

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
PANC-1	Pancreatic ductal adenocarcinoma	IC50>120 μM	MTT assay	2 h	1
A549	Lung adenocarcinoma	IC50>160 μM	MTT assay	2 h	1

Hemolytic Activity Human erythrocytes: 0% Hemolysis=30 µM

Normal (non-cancerous) Cytotoxicity MCF-10A: IC50>120 μM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02377

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C71H107N17O15

Absent amino acids CDEIKMNPQRTVWY

Theoretical pI 6.92

Acidic residues 0

Basic residues 2

Polar residues 2

Molecular weight (Average) 1438.74

Molecular weight (Monoisotopic) 1437.81

Common amino acids L

Net charge 2

Instability index (II) 2.7

Aliphatic index 165.38

Grand average of hydropathicity (GRAVY) 1.585

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22526264

Title Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria

Doi 10.1007/s00203-012-0810-5

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_4526