Peptide Libraray

LL-1

General Information

DCTPep ID DCTPep02378

Peptide Name LL-1

Sequence FLGALWKALSKLL

Sequence Length 13

UniProt ID P80399

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50=9 μM	MTT assay	2 h	1
PANC-1	Pancreatic ductal adenocarcinoma	IC50=9 μM	MTT assay	2 h	1

Hemolytic Activity Human erythrocytes: 41% Hemolysis=30 µM

Normal (non-cancerous) Cytotoxicity MCF-10A: IC50=9 μM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02378

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C73H118N16O15

Absent amino acids CDEHIMNPQRTVY

Theoretical pI 10.00

Acidic residues 0

Basic residues 2

Polar residues 2

Molecular weight (Average) 1459.84

Molecular weight (Monoisotopic) 1458.9

Common amino acids L

Net charge 2

Instability index (II) 14.38

Aliphatic index 165.38

Grand average of hydropathicity (GRAVY) 1.192

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.768

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22526264

Title Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria

Doi 10.1007/s00203-012-0810-5

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_13991