LL-1

General Information


DCTPep ID  DCTPep02378

Peptide Name   LL-1

Sequence  FLGALWKALSKLL

Sequence Length  13

UniProt ID  P80399 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane lysis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma IC50=9 μM MTT assay 2 h 1
PANC-1 Pancreatic ductal adenocarcinoma IC50=9 μM MTT assay 2 h 1

Hemolytic Activity  Human erythrocytes: 41% Hemolysis=30 µM

Normal (non-cancerous) Cytotoxicity  MCF-10A: IC50=9 μM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02378

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C73H118N16O15

Absent amino acids  CDEHIMNPQRTVY

Theoretical pI  10.00

Acidic residues  0

Basic residues  2

Polar residues  2

Molecular weight (Average)  1459.84

Molecular weight (Monoisotopic)  1458.9

Common amino acids  L

Net charge  2

Instability index (II)  14.38

Aliphatic index  165.38

Grand average of hydropathicity (GRAVY)  1.192

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 3.768

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 22526264

Title  Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria

Doi 10.1007/s00203-012-0810-5

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_13991

DCTPep is developed by Dr.Zheng's team.