Peptide Libraray

LL-1a

General Information

DCTPep ID DCTPep02379

Peptide Name LL-1a

Sequence FLGALWHALSKLL

Sequence Length 13

UniProt ID P80399

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50=22 μM	MTT assay	2 h	1
PANC-1	Pancreatic ductal adenocarcinoma	IC50=39 μM	MTT assay	2 h	1

Hemolytic Activity Human erythrocytes: 15% Hemolysis=30 µM

Normal (non-cancerous) Cytotoxicity MCF-10A: IC50=65 μM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02379

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C73H113N17O15

Absent amino acids CDEIMNPQRTVY

Theoretical pI 8.76

Acidic residues 0

Basic residues 2

Polar residues 2

Molecular weight (Average) 1468.8

Molecular weight (Monoisotopic) 1467.86

Common amino acids L

Net charge 2

Instability index (II) 32.6

Aliphatic index 165.38

Grand average of hydropathicity (GRAVY) 1.246

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.745

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 22526264

Title Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria

Doi 10.1007/s00203-012-0810-5

Year 2012

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_13992