Peptide Libraray

L5c

General Information

DCTPep ID DCTPep02392

Peptide Name L5c

Sequence PAWRHAFHWAWHMLHKAA

Sequence Length 18

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50>80 μM(pH=7.4); IC50=12 ± 2 μM(pH=5.5)	MTT assay	2 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity CHO: IC50=67 ± 3 μM(pH=7.4); IC50=7 ± 2 μM(pH=5.5)

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02392

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C109H145N33O19S1

Absent amino acids CDEGINQSTVY

Theoretical pI 11.01

Acidic residues 0

Basic residues 6

Polar residues 0

Molecular weight (Average) 2253.62

Molecular weight (Monoisotopic) 2252.11

Common amino acids A

Net charge 6

Instability index (II) 47.21

Aliphatic index 49.44

Grand average of hydropathicity (GRAVY) -0.444

Half Life
>20 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
? (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 7.322

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 19464332

Title Constructing bioactive peptides with pH-dependent activities

Doi 10.1016/j.peptides.2009.05.009

Year 2009

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_4530