Peptide Libraray

Citropin-a

General Information

DCTPep ID DCTPep02393

Peptide Name Citropin-a

Sequence GLFAVIHKVASVIGGL

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	IC50=56±3 μM(pH=7.4); IC50=44±3 μM(pH=5.5)	MTT assay	2 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity CHO: IC50=78 ± 2 μM(pH=7.4); IC50=47 ± 3 μM(pH=5.5)

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02393

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C75H125N19O18

Absent amino acids CDEMNPQRTWY

Theoretical pI 8.76

Acidic residues 0

Basic residues 2

Polar residues 4

Molecular weight (Average) 1580.93

Molecular weight (Monoisotopic) 1579.94

Common amino acids GV

Net charge 2

Instability index (II) 34.29

Aliphatic index 164.37

Grand average of hydropathicity (GRAVY) 1.656

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 19464332

Title Constructing bioactive peptides with pH-dependent activities

Doi 10.1016/j.peptides.2009.05.009

Year 2009

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_4532