Citropin-b

General Information


DCTPep ID  DCTPep02394

Peptide Name   Citropin-b

Sequence  GLFAVIKHVASVIGGL

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane lysis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
A549 Lung adenocarcinoma IC50=97 ± 4 μM(pH=7.4); IC50=61±3 μM(pH=5.5) MTT assay 2 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  CHO: IC50=76 ± 4 μM(pH=7.4); IC50=41 ± 5 μM(pH=5.5)

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02394

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C75H125N19O18

Absent amino acids  CDEMNPQRTWY

Theoretical pI  8.76

Acidic residues  0

Basic residues  2

Polar residues  4

Molecular weight (Average)  1580.93

Molecular weight (Monoisotopic)  1579.94

Common amino acids  GV

Net charge  2

Instability index (II)  11.78

Aliphatic index  164.37

Grand average of hydropathicity (GRAVY)  1.656

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 19464332

Title  Constructing bioactive peptides with pH-dependent activities

Doi 10.1016/j.peptides.2009.05.009

Year  2009

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_4533

DCTPep is developed by Dr.Zheng's team.