This work is licensed under a Creative Commons Attribution 4.0 International License.
MAP-04-03
General Information
DCTPep ID DCTPep02398
Peptide Name MAP-04-03
Sequence KWLRRVWRWWR
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50=61.5 μM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C85H122N28O12
Absent amino acids ACDEFGHIMNPQSTY
Theoretical pI 12.48
Acidic residues 0
Basic residues 5
Polar residues 0
Molecular weight (Average) 1728.08
Molecular weight (Monoisotopic) 1726.98
Common amino acids RW
Net charge 5
Instability index (II) 141.96
Aliphatic index 61.82
Grand average of hydropathicity (GRAVY) -1.591
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 22000
Abs 0.1% (=1 g/l) 12.731
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23993331
Title Anticancer activities of an antimicrobial peptide derivative of Ixosin-B amide
Doi 10.1016/j.bmcl.2013.07.063
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4584
This work is licensed under a Creative Commons Attribution 4.0 International License.