Temporin-1Sa [S3K,F13W], SEQ ID NO:6 for Patent EP 2853538 A1

General Information


DCTPep ID  DCTPep02406

Peptide Name   Temporin-1Sa [S3K,F13W], SEQ ID NO:6 for Patent EP 2853538 A1

Sequence  FLKGIVGMLGKLW

Sequence Length  13

UniProt ID  B3KYH4 

PubChem CID  Not available

Origin  Synthetic (Derived from Temporin-1Sa)

Type  Synthetic peptide

Classification

  

ACP



Activity Information


Hemolytic Activity  Rat erythrocytes: LC50=32 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02406

(Please note that there is the predicted structure, predicted by AlphaFold)

Parsing response... [0/0]
SequenceNo structure available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C72H116N16O14S1

Absent amino acids  ACDEHNPQRSTY

Theoretical pI  10.00

Acidic residues  0

Basic residues  2

Polar residues  3

Molecular weight (Average)  1461.87

Molecular weight (Monoisotopic)  1460.86

Common amino acids  GL

Net charge  2

Instability index (II)  -18.27

Aliphatic index  142.31

Grand average of hydropathicity (GRAVY)  1.146

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 3.762

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID EP 2853538 A1

Patent Title  Analogues of temporin-SHa and uses thereof

Other Iinformation  Patent Application; Family: 11s / 11ex; Family Jurisdictions: CA, EP, JP, BR, US, WO, ES; Legal Status: Discontinued; Application No: 13306344; Filed: Sep 27, 2013; Published: Apr 1, 2015; Earliest Priority: Sep 27, 2013

Other Published ID  BR112016006424A2  CA2924035A1  EP3049432A1  EP3049432B1  ES2691323T3  JP2016539658A  JP6669656B2  US2016280749A1  US9932376B2  WO2015044356A1 




DBAASP ID  DBAASPS_9113

DCTPep is developed by Dr.Zheng's team.