Temporin-1Sa [S3K,F13W], SEQ ID NO:6 for Patent EP 2853538 A1
General Information
DCTPep ID DCTPep02406
Peptide Name Temporin-1Sa [S3K,F13W], SEQ ID NO:6 for Patent EP 2853538 A1
Sequence FLKGIVGMLGKLW
Sequence Length 13
UniProt ID B3KYH4
PubChem CID Not available
Origin Synthetic (Derived from Temporin-1Sa)
Type Synthetic peptide
Classification
ACP
Activity Information
Hemolytic Activity Rat erythrocytes: LC50=32 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02406
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C72H116N16O14S1
Absent amino acids ACDEHNPQRSTY
Theoretical pI 10.00
Acidic residues 0
Basic residues 2
Polar residues 3
Molecular weight (Average) 1461.87
Molecular weight (Monoisotopic) 1460.86
Common amino acids GL
Net charge 2
Instability index (II) -18.27
Aliphatic index 142.31
Grand average of hydropathicity (GRAVY) 1.146
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.762
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID EP 2853538 A1
Patent Title Analogues of temporin-SHa and uses thereof
Other Iinformation Patent Application; Family: 11s / 11ex; Family Jurisdictions: CA, EP, JP, BR, US, WO, ES; Legal Status: Discontinued; Application No: 13306344; Filed: Sep 27, 2013; Published: Apr 1, 2015; Earliest Priority: Sep 27, 2013
Other Published ID BR112016006424A2 CA2924035A1 EP3049432A1 EP3049432B1 ES2691323T3 JP2016539658A JP6669656B2 US2016280749A1 US9932376B2 WO2015044356A1
External Code
DBAASP ID DBAASPS_9113