M2

General Information


DCTPep ID  DCTPep02408

Peptide Name   M2

Sequence  KRKILILILIL

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer therapy related peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
U-937 Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia LD50>64 µM CytoTox 96 non-radiactive cytotoxicity assay  2 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C66H126N16O12

Absent amino acids  ACDEFGHMNPQSTVWY

Theoretical pI  11.17

Acidic residues  0

Basic residues  3

Polar residues  0

Molecular weight (Average)  1335.83

Molecular weight (Monoisotopic)  1334.97

Common amino acids  IL

Net charge  3

Instability index (II)  101.05

Aliphatic index  283.64

Grand average of hydropathicity (GRAVY)  1.900

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 25192319

Title  Rational design of artificial β-strand-forming antimicrobial peptides with biocompatible properties

Doi 10.1021/mp500271c

Year  2014

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_8932

DCTPep is developed by Dr.Zheng's team.