This work is licensed under a Creative Commons Attribution 4.0 International License.
H7
General Information
DCTPep ID DCTPep02435
Peptide Name H7
Sequence KRKGKRK
Sequence Length 7
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | LD50>64 µM | CytoTox 96 non-radiactive cytotoxicity assay | 2 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C38H77N17O8
Absent amino acids ACDEFHILMNPQSTVWY
Theoretical pI 12.03
Acidic residues 0
Basic residues 6
Polar residues 1
Molecular weight (Average) 900.14
Molecular weight (Monoisotopic) 899.61
Common amino acids K
Net charge 6
Instability index (II) 77.46
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -3.571
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25192319
Title Rational design of artificial β-strand-forming antimicrobial peptides with biocompatible properties
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_9141
This work is licensed under a Creative Commons Attribution 4.0 International License.