Peptide Libraray

General Information

DCTPep ID DCTPep02449

Peptide Name S8

Sequence KKKFFFFFKKK

Sequence Length 11

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
U-937	Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia	LD50>64 µM	CytoTox 96 non-radiactive cytotoxicity assay	2 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C81H119N17O12

Absent amino acids ACDEGHILMNPQRSTVWY

Theoretical pI 10.70

Acidic residues 0

Basic residues 6

Polar residues 0

Molecular weight (Average) 1522.94

Molecular weight (Monoisotopic) 1521.92

Common amino acids K

Net charge 6

Instability index (II) -4.57

Aliphatic index 0.00

Grand average of hydropathicity (GRAVY) -0.855

Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 25192319

Title Rational design of artificial β-strand-forming antimicrobial peptides with biocompatible properties

Doi 10.1021/mp500271c

Year 2014

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_9173