This work is licensed under a Creative Commons Attribution 4.0 International License.
[TOAC1, Api4] TG
General Information
DCTPep ID DCTPep02460
Peptide Name [TOAC1, Api4] TG
Sequence XGLXGGLXGIX
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from TG)
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| T67 | Astrocytoma | EC50=8 μM | MTT assay | 24 h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Not active up to 20 μM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Human dermal fibroblasts: Not active up to 20 μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Oct (Fatty acid 1-Octanoyl)
C-terminal Modification Free
Other Modification X(1)=TOAC; X(4)=Api; X(8)=Aib; X(11)=Lol (Amino alcohol leucinol)
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27039838
Title The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_9806
This work is licensed under a Creative Commons Attribution 4.0 International License.