Peptide Libraray

[D-Lys8] Ascaphin-8

General Information

DCTPep ID DCTPep02472

Peptide Name [D-Lys8] Ascaphin-8

Sequence GFKDLLKkAAKALVKTVLF

Sequence Length 19

UniProt ID P0CJ32

PubChem CID Not available

Origin Synthetic (Derived from Ascaphin-8)

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HepG2	Hepatoblastoma	LC50=15 µM	CytoTox 96 non-radiactive cytotoxicity assay	1 h	1

Hemolytic Activity Human erythrocytes: LC50=150 µM

Normal (non-cancerous) Cytotoxicity L929 fibroblast-derived cells: LC50=9 µM

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral Mix

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 18554256

Title Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7

Doi 10.1111/j.1747-0285.2008.00671.x

Year 2008

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_4911