This work is licensed under a Creative Commons Attribution 4.0 International License.
[D-Lys18] Ascaphin-8
General Information
DCTPep ID DCTPep02475
Peptide Name [D-Lys18] Ascaphin-8
Sequence GFKDLLKGAAKALVKTVkF
Sequence Length 19
UniProt ID P0CJ32
PubChem CID Not available
Origin Synthetic (Derived from Ascaphin-8)
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | LC50=140 µM | CytoTox 96 non-radiactive cytotoxicity assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: LC50>500 µM
Normal (non-cancerous) Cytotoxicity L929 fibroblast-derived cells: LC50=65 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18554256
Title Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7
Doi 10.1111/j.1747-0285.2008.00671.x
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4915
This work is licensed under a Creative Commons Attribution 4.0 International License.