[Lys5] XT-7

General Information


DCTPep ID  DCTPep02480

Peptide Name   [Lys5] XT-7

Sequence  GLLGKLLKIAAKVGSNLL

Sequence Length  18

UniProt ID  P84381 

PubChem CID  Not available

Origin  Synthetic (Derived from XT-7)

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane lysis



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HepG2 Hepatoblastoma LC50=14 µM CytoTox 96 non-radiactive cytotoxicity assay  1 h 1

Hemolytic Activity  Human erythrocytes: LC50=15 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02480

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C84H154N22O21

Absent amino acids  CDEFHMPQRTWY

Theoretical pI  10.30

Acidic residues  0

Basic residues  3

Polar residues  5

Molecular weight (Average)  1808.28

Molecular weight (Monoisotopic)  1807.17

Common amino acids  L

Net charge  3

Instability index (II)  -18.86

Aliphatic index  178.89

Grand average of hydropathicity (GRAVY)  0.994

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 18554256

Title  Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7

Doi 10.1111/j.1747-0285.2008.00671.x

Year  2008

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_4922

DCTPep is developed by Dr.Zheng's team.