P6 (SEQ ID NO:1 for Patent US 20030186868 A1)

General Information


DCTPep ID  DCTPep02487

Peptide Name   P6 (SEQ ID NO:1 for Patent US 20030186868 A1)

Sequence  RRPKGRGKRRREKQRP

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Cancer targeted peptides Antiangiogenic Antagonists of VEGF165 signaling through



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  VEGF165

Affinity  Not available

Mechanism  Its mechanism that involves competition for VEGF165 binding at either the VEGFR-2/NP-1 complex or NP-1, without affecting VEGF signaling through other pathways.



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep02487

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C84H157N41O20

Absent amino acids  ACDFHILMNSTVWY

Theoretical pI  12.40

Acidic residues  1

Basic residues  10

Polar residues  2

Molecular weight (Average)  2061.43

Molecular weight (Monoisotopic)  2060.25

Common amino acids  R

Net charge  9

Instability index (II)  160.11

Aliphatic index  0.00

Grand average of hydropathicity (GRAVY)  -3.388

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  2 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US 20030186868 A1

Patent Title  Anti-angiogenic peptides

Other Iinformation  Patent Application; Family: 5s / 5ex; Family Jurisdictions: AU, US, WO; Legal Status: Expired; Application No: 26316202; Filed: Oct 2, 2002; Published: Oct 2, 2003; Earliest Priority: Oct 3, 2001; Granted: May 30, 2006

Other Published ID  AU2002340080A1  US7052705B2  WO03029275A2  WO03029275A3 




DCTPep is developed by Dr.Zheng's team.