DCTPep ID  DCTPep02491

Peptide Name   P6V8-3NCS1-7CC (SEQ ID NO:12 for Patent US 20030186868 A1)

Sequence  CKGRGKRCREKQRPSDKPRR

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  VEGF165

Affinity  Not available

Mechanism  Its mechanism that involves competition for VEGF165 binding at either the VEGFR-2/NP-1 complex or NP-5, without affecting VEGF signaling through other pathways.

PDB ID  Not available

Predicted Structure  DCTPep02491

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys1<--->Cys8

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  -2.645

Half Life 
  1.2 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 125
  Abs 0.1% (=1 g/l) 0.051, assuming all pairs of Cys residues form cystines
  Ext. coefficient 0
  Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution

Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID US 20030186868 A1

Patent Title  Anti-angiogenic peptides

Other Iinformation  Patent Application; Family: 5s / 5ex; Family Jurisdictions: AU, US, WO; Legal Status: Expired; Application No: 26316202; Filed: Oct 2, 2002; Published: Oct 2, 2003; Earliest Priority: Oct 3, 2001; Granted: May 30, 2006

Other Published ID  AU2002340080A1  US7052705B2  WO03029275A2  WO03029275A3