This work is licensed under a Creative Commons Attribution 4.0 International License.
P6V8-3NCSA7,8,10 (SEQ ID NO:33 for Patent US 20030186868 A1)
General Information
DCTPep ID DCTPep02505
Peptide Name P6V8-3NCSA7,8,10 (SEQ ID NO:33 for Patent US 20030186868 A1)
Sequence KGRGKRAAEAQRPSDKPRR
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Cancer targeted peptides Antiangiogenic Antagonists of VEGF165 signaling through
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target VEGF165
Affinity Not available
Mechanism Its mechanism that involves competition for VEGF165 binding at either the VEGFR-2/NP-1 complex or NP-19, without affecting VEGF signaling through other pathways.
Structure Information
PDB ID Not available
Predicted Structure DCTPep02505
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C88H158N38O26
Absent amino acids CFHILMNTVWY
Theoretical pI 11.84
Acidic residues 2
Basic residues 8
Polar residues 3
Molecular weight (Average) 2164.46
Molecular weight (Monoisotopic) 2163.22
Common amino acids R
Net charge 6
Instability index (II) 51.24
Aliphatic index 15.79
Grand average of hydropathicity (GRAVY) -2.321
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US 20030186868 A1
Patent Title Anti-angiogenic peptides
Other Iinformation Patent Application; Family: 5s / 5ex; Family Jurisdictions: AU, US, WO; Legal Status: Expired; Application No: 26316202; Filed: Oct 2, 2002; Published: Oct 2, 2003; Earliest Priority: Oct 3, 2001; Granted: May 30, 2006
Other Published ID AU2002340080A1 US7052705B2 WO03029275A2 WO03029275A3
This work is licensed under a Creative Commons Attribution 4.0 International License.