This work is licensed under a Creative Commons Attribution 4.0 International License.
Chemokinostatin-6
General Information
DCTPep ID DCTPep02512
Peptide Name Chemokinostatin-6
Sequence NGKQVCLDPEAPFLKKVIQKILDS
Sequence Length 24
UniProt ID P80162
PubChem CID Not available
Origin Homo sapiens (CXCL6/GCP-2)
Type Native peptide
Classification
Cancer targeted peptides Antiangiogenic
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target CXCR
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02512
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C121H203N31O35S1
Absent amino acids HMRTWY
Theoretical pI 8.16
Acidic residues 3
Basic residues 4
Polar residues 4
Molecular weight (Average) 2684.19
Molecular weight (Monoisotopic) 2682.48
Common amino acids K
Net charge 1
Instability index (II) 43.26
Aliphatic index 109.58
Grand average of hydropathicity (GRAVY) -0.212
Half Life
1.4 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18307172
Title Novel anti-angiogenic peptides derived from ELR-containing CXC chemokines
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.