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C20
General Information
DCTPep ID DCTPep02517
Peptide Name C20
Sequence KKIMRTFLRRISKDILTGKK
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Membrane lysis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Not active up to 100μg/ml | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=100 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02517
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C109H198N34O26S1
Absent amino acids ACEHNPQVWY
Theoretical pI 11.75
Acidic residues 1
Basic residues 8
Polar residues 4
Molecular weight (Average) 2433.04
Molecular weight (Monoisotopic) 2431.49
Common amino acids K
Net charge 7
Instability index (II) 47.07
Aliphatic index 97.50
Grand average of hydropathicity (GRAVY) -0.665
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17389605
Title Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_5051
This work is licensed under a Creative Commons Attribution 4.0 International License.